General Information

Full Name Lei Xiong
Contact jsxlei [at] gmail [dot] com

Research Areas

  • My PhD research focuses on developing artificial intelligence tool for analysis of single-cell RNA-seq and ATAC-seq data to uncover gene regulation in cell heterogeneity. In my PhD dissertation, “Artificial intelligence method for single-cell ATAC-seq data via feature extraction”, I studied analysis methods for uncovering the regulatory variations across various cell types observed from high-dimensional and sparse single-cell ATAC-seq data.
  • I am also passionate about applying network analysis methods. Previously, I did some research in structural-protein-protein interaction (PPI) network to find out structural modules enriching cancer mutations and drug targets.


  • 2015 - 2020
    Tsinghua University – Ph.D. in Computational Biology
  • 2011 - 2015
    University of Science and Technology of China – B.S. in Biology
    • Advised by Prof. Nieng Yan
    • Thesis: Structure basis and transport mechanism of membrane protein GLUT3

Other Research Experience

  • 2013 - 2014
    Research for Undergraduates Program
    • University of Science and Technology of China
    • Advised by Prof. Jianye Zang
    • Structure and function research of ubiquitin ligase TRAIP (TRAF-interacting protein) including molecular clone, protein expression and purification, pull down, inclusion body denaturation and renaturation experiments.
  • 2012 - 2013
    2013 USTC-China iGEM Team
    • University of Science and Technology of China
    • In Situ Transdermal Vaccine. We constructed a macromolecule transdermal delivery system with the support of TD-1 polypeptide in Bacillus subtilis. We also designed a reporter system and a kill switch for usability and biosafety.
Note: for further details on my research, please see the publications page.


  • ○ Designing artificial intelligence algorithm for biological problems
  • ○ Biological data mining
  • ○ Single-cell analysis
  • ○ Network analysis
  • ○ Frameworks: Pytorch, Tensorflow, NumPy, SciPy, Pandas.